Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting

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FIGURE 4.
FIGURE 4.

Most common chemical modifications introduced in siRNAs. (A) Phosphodiester modifications: unmodified siRNA (phosphodiester RNA); phosphorothioate RNA; boranophosphonate. (B) 2′-Sugar modifications: 2′-O-Methyl RNA; 2′-deoxy-2′-fluoro RNA; locked nucleic acid (LNA).

This Article

  1. Published in Advance February 28, 2007, doi: 10.1261/rna.459807 RNA 13: 431-456

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