The bunyavirus nucleocapsid protein is an RNA chaperone: Possible roles in viral RNA panhandle formation and genome replication

Disorder in hantavirus N protein. In A the relative disorder of hantavirus N protein is compared to that of the three other known RNA chaperone proteins. The “PONDR” plot for the N sequence is shown in panel B. Amino acid sequences that score >0.5 are considered likely to be disordered. The SNV N protein has two putative disordered domains that are 77 and 46 amino acids in length. A ClustalW alignment of the putative disordered region of four diverse hantavirus species is shown in panel C. Shaded amino acids are conserved, while unshaded amino acids are divergent.