The bunyavirus nucleocapsid protein is an RNA chaperone: Possible roles in viral RNA panhandle formation and genome replication

P-num analysis of the hantavirus S segment. The P-num values of the entire S segment along the length of the negative sense vRNA are shown in A. Plus stranded S segment cRNA contains the N gene. At the top of the plot is shown the location of the region complementary to the N gene in the vRNA S segment. An expanded view of the P-num values for the terminal nucleotides is shown in B. C compares the distribution of P-num values in S segment vRNA, S segment cRNA, and in a randomized vRNA sequence. The P-num values for the S segment vRNA are greater than those of the cRNA or the randomized vRNA sequence.