The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells

LTR-247 sense/antisense and antisense alone are capable of targeting the U3 region of the HIV-1 LTR and inhibiting Tat-mediated expression of fire fly luciferase in 1G5 cells. Results are from four independent experiments measured 24 h post-transfection with log relative expression and standard error of the means shown. Values represent luciferase expression relative to the experimental mean.