mRNA with a <20-nt poly(A) tail imparted by the poly(A)-limiting element is translated as efficiently in vivo as long poly(A) mRNA

TABLE 1.

Capped and polyadenylated mRNAs

Poly(A) length
luc mRNA 5′ end A0 A14 A20 A54 A98
Control ApppG X X
7mGpppG X X X X X
+PLE ApppG X X
7mGpppG X X X X X

This Article

  1. Published in Advance May 31, 2005, doi: 10.1261/rna.2470905 RNA 11: 1131-1140

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